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Cohort study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

《医学前沿（英文）》 2021年 第15卷 第4期   页码 585-593 doi: 10.1007/s11684-020-0817-2

摘要： Stevens--Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe diseases. This study aimed to validate the predictive ability of risk models in patients with SJS/TEN and propose possible refinement in China. Patients in the Department of Dermatology of Huashan Hospital from January 2008 to January 2019 were included. Results showed that the severity-of-illness score for TEN (SCORTEN) had a good discrimination (area under the receiver operating characteristic curve (AUC), 0.78), and it was superior to auxiliary score (AS) and ABCD-10, which indicates age, bicarbonate level, cancer, dialysis, and 10% involved body surface area (AUC, 0.69 and 0.68, respectively). The calibration of SCORTEN (Hosmer–Lemeshow goodness-of-fit test, = 0.69) was also better than that of AS ( = 0.25) and ABCD-10 ( = 0.55). SCORTEN and ABCD-10 were similar (Brier score (BS), 0.04 and 0.04) in terms of accuracy of predictions. In addition, the imaging appearance of pulmonary consolidation on computed tomography was associated with high mortality. Refined models were formed using the variables and this imaging appearance. The refined AS and ABCD-10 models were similar in discrimination compared with the original SCORTEN (0.74 vs. 0.78, = 0.23; 0.74 vs. 0.78, = 0.30, respectively). Therefore, SCORTEN showed good discrimination performance, calibration, and accuracy, and refined AS or ABCD-10 model may be an option when SCORTEN variables are not available.

关键词： Stevens–Johnson syndrome     toxic epidermal necrolysis     auxiliary score     ABCD-10     pulmonary consolidation    

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Toxic effects of enrofloxacin on

Hongwei QIN, Liufang CHEN, Nan LU, Yahui ZHAO, Xing YUAN

《环境科学与工程前沿（英文）》 2012年 第6卷 第1期   页码 107-116 doi: 10.1007/s11783-011-0327-1

摘要： In this article, the toxic effects of Enrofloxacin (ENFX) on were studied, through investigating the growth, photosynthetic pigments, and protein contents. The possible toxic mechanisms of ENFX were analyzed by determining the superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, proline content, and superoxide anion ( ) generation rate. Results showed that the growth of algae was inhibited by ENFX and the 50% effective concentration (EC ) values for 24, 48, 72, and 96 h of ENFX were 88.39, 63.86, 45.10, and 59.16 mg·L , respectively. After treated with ENFX for 96 h, the contents of photosynthetic pigments decreased with the increase of ENFX concentration, the content of soluble protein and the activity of SOD increased and then decreased, and the generation rate of superoxide anion ( ) increased continually. The contents of MDA and proline changed little in lower ENFX concentration groups, but increased rapidly when treated with higher concentration groups. These results suggested that ENFX affected the growth of , and the main toxicity mechanism was that algal cells generated the reactive oxygen species under ENFX stress, and then the reactive oxygen species (ROS) induced the oxidation damages of biologic macromolecules and changed the biomembrane permeability further.

关键词： enrofloxacin     Scenedesmus obliquus     toxic effects    

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Removal and recovery of toxic nanosized Cerium Oxide using eco-friendly Iron Oxide Nanoparticles

Kanha Gupta, Nitin Khandelwal, Gopala Krishna Darbha

《环境科学与工程前沿（英文）》 2020年 第14卷 第1期 doi: 10.1007/s11783-019-1194-4

摘要： Eco-friendly IONPs were synthesized through solvothermal method. IONPs show very high removal efficiency for CeO2 NPs i.e. 688 mg/g. Removal was >90% in all synthetic and real water samples. >80% recovery of CeO2 NPs through sonication confirms reusability of IONPs. Increasing applications of metal oxide nanoparticles and their release in the natural environment is a serious concern due to their toxic nature. Therefore, it is essential to have eco-friendly solutions for the remediation of toxic metal oxides in an aqueous environment. In the present study, eco-friendly Iron Oxide Nanoparticles (IONPs) are synthesized using solvothermal technique and successfully characterized using scanning and transmission electron microscopy (SEM and TEM respectively) and powder X-Ray diffraction (PXRD). These IONPs were further utilized for the remediation of toxic metal oxide nanoparticle, i.e., CeO2. Sorption experiments were also performed in complex aqueous solutions and real water samples to check its applicability in the natural environment. Reusability study was performed to show cost-effectiveness. Results show that these 200 nm-sized spherical IONPs, as revealed by SEM and TEM analysis, were magnetite (Fe3O4) and contained short-range crystallinity as confirmed from XRD spectra. Sorption experiments show that the composite follows the pseudo-second-order kinetic model. Further R2>0.99 for Langmuir sorption isotherm suggests chemisorption as probable removal mechanism with monolayer sorption of CeO2 NPs on IONP. More than 80% recovery of adsorbed CeO2 NPs through ultrasonication and magnetic separation of reaction precipitate confirms reusability of IONPs. Obtained removal % of CeO2 in various synthetic and real water samples was>90% signifying that IONPs are candidate adsorbent for the removal and recovery of toxic metal oxide nanoparticles from contaminated environmental water samples.

关键词： Adsorption     toxic metal oxide remediation     eco-friendly IONP     Iron oxide     CeO2 removal    

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Nanosized magnetite in low cost materials for remediation of water polluted with toxic metals, azo- and

María Fernanda HORST,Verónica LASSALLE,María Luján FERREIRA

《环境科学与工程前沿（英文）》 2015年 第9卷 第5期   页码 746-769 doi: 10.1007/s11783-015-0814-x

摘要： Nanosized magnetite has emerged as an adsorbent of pollutants in water remediation. Nanoadsorbents include magnetic iron oxide and its modifiers/stabilizers, such as carbon, silica, clay, organic moieties (polymers, aminoacids, and fatty acids) and other inorganic oxides. This review is focused on the recent developments on the synthesis and use of magnetic nanoparticles and nanocomposites in the treatment of contaminated water. The emphasis is on the influence of the iron oxide modifiers on some properties of interest such as size, BET area, and magnetization. The characteristics of these nanomaterials are related to their ability to eliminate heavy metal ions and dyes from wastewater. Comparative analysis of the actual literature was performed aiming to present the magnetic material, its preparation methodology and performance in the elimination of the selected pollutants. Vast information has been properly summarized according to the materials, their properties and preferential affinity for selected contaminants. The mechanisms governing nanomaterial’s formation as well as the interactions with heavy metals and dyes have been carefully analyzed and associated to their efficiency.

关键词： nanomagnetite     water remediation     toxic metals     dyes     supported magnetite    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

《医学前沿（英文）》 2021年 第15卷 第2期   页码 208-220 doi: 10.1007/s11684-020-0795-4

摘要： New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

关键词： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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fabricating photoluminescent carbon dots and its potential application as an efficient sensor probe for toxic

《化学科学与工程前沿（英文）》 2023年 第17卷 第5期   页码 536-547 doi: 10.1007/s11705-022-2239-y

摘要： The past decade has witnessed a variety of members of the carbon family along with exposure of carbon dots due to their magnificent properties in sensing, bioimaging, catalytic applications, biomedical fields, and so on. Herein, we report the simple hydrothermal method to fabricate photoluminescent doped carbon quantum dots for the detection of noxious lead(II) ions. Lead(II) ion is very venomous for both the environment and human health for which its detection is demanded area in the research field. The as-prepared carbon dots show excellent photostability, low toxicity and significant photoluminescence properties along with good water solubility. Along with these properties, carbon dots have a quantum yield of approximately 15%. In the practical field of application, these carbon dots have been used as sensing probes for the detection of lead(II) ions with a detection limit of 60 nmol·L–1. The fluorescence intensity of carbon dots was remarkably quenched in the presence of the lead(II) ion selectively among all the tested metal ions. Furthermore, we have studied the Stern–Volmer relationship for lead(II) quenching along with the explanation of the probable quenching mechanism. Ability of the doped carbon dots in heavy metal ions sensing in an environmental sample was demonstrated.

关键词： carbon dots     fluorescence     heavy metal sensing     practical application     photoluminescence    

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Impact and inhibitory mechanism of phenolic compounds on the formation of toxic Maillard reaction products

Jing TENG, Xiaoqian HU, Ningping TAO, Mingfu WANG

《农业科学与工程前沿（英文）》 2018年 第5卷 第3期   页码 321-329 doi: 10.15302/J-FASE-2017182

摘要：

As one of the dominant reactions occurring during thermal treatment of food, the Maillard reaction not only leads to the formation of aroma, browning color and taste compounds, but also contributes to the formation of some unpleasant toxic substances including acrylamide, heterocyclic amines and advanced glycation end products. Polyphenols, one of the most abundant antioxidants in the human diet, are contained in different kinds of foods. In this review, some recent studies on the impact of dietary polyphenols on the formation of acrylamide, heterocyclic amines and advanced glycation end products formed during the Maillard reaction are summarized, including the research work conducted with both chemical model systems and real food model systems; the possible inhibitory mechanisms of different polyphenols are also summarized and discussed in this review. Basically we found that some dietary polyphenols not only scavenge free radicals, but also react with reactive carbonyl species, thus lowering the formation of toxic Maillard reaction products. This review provides a useful theoretical foundation for the application of polyphenols in food safety, and suggests some directions for further study of natural products as inhibitors against the formation of toxic substances in thermally processed food.

关键词： advanced glycation end products     acrylamide     food safety     heterocyclic amine     Maillard reaction     polyphenols    

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Concentrations of toxic heavy metals in ambient particulate matter in an industrial area of northeastern

PIAO Fengyuan, SUN Xiance, LIU Shuang, YAMAUCHI Toru

《医学前沿（英文）》 2008年 第2卷 第2期   页码 207-210 doi: 10.1007/s11684-008-0040-z

摘要： This paper investigates concentrations of various heavy metals in ambient particulate matter (PM) and provide evidence for prevention from air pollution. The concentrations of heavy metal components in the PM were determined by inductively coupled plasma/Mass spectrometry (ICP/MS) from September 2000 to August 2002 in a northeast industrial city in China. Concentrations of Cd, Mn, Pb, Ni, Cr and As in the PM were 9.3, 461.9, 588.7, 69.5, 205.7 and 57.4 ng/m in the industrial area, and 5.7, 245.5, 305.0, 31.4, 58.8 and 32.5 ng/m in the main road, respectively. Concentrations of these heavy metals except Cd were significantly higher in the industrial area and main road than those in the suburban area ( < 0.05 or < 0.01). The change curves of the six heavy metal concentrations show their concentrations increased in the winter and spring, but decreased in the summer and autumn. The results indicate that concentrations of the metals in the PM are relatively high in the industrial area and main road.

关键词： summer     August     northeast industrial     September     spring    

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Insight into fluorescence properties of 14 selected toxic single-ring aromatic compounds in water: Experimental

Muhammad Farooq Saleem Khan, Jing Wu, Cheng Cheng, Mona Akbar, Chuanyang Liu, Bo Liu, Jian Shen, Yu Xin

《环境科学与工程前沿（英文）》 2020年 第14卷 第3期 doi: 10.1007/s11783-020-1219-z

摘要： The fluorescence peak location of 14 compounds interpreted at protein-like region. The p-electron system inside aromatic ring contributes to the fluorophore region. Functional group variation effects the emission spectra. Decrease in quantum yield and increase in DE is due to atomic weight F>Cl>Br>I. Theoretically results are in line with experimental ones. Various single-ring aromatic compounds in water sources are of great concern due to its hazardous impact on the environment and human health. The fluorescence excitation-emission matrix (EEMs) spectrophotometry is a useful method to identify organic pollutants in water. This study provides a detailed insight into the fluorescence properties of the 14 selected toxic single-ring aromatic compounds by experimental and theoretical analysis. The theoretical analysis were done with Time-Dependent Density Functional Theory (TD-DFT) and B3LYP/6-31G (d,p) basis set, whereas, Polarizable Continuum Model (PCM) was used to consider water as solvent. The selected compounds displayed their own specific excitation-emission (Ex/Em) wavelengths region, at Ex<280 nm and Em<340 nm, respectively. Whereas the theoretical Ex/Em was observed as, Ex at 240 nm–260 nm and Em at 255 nm–300 nm. Aniline as a strong aromatic base has longer Em (340 nm) than alkyl, carbonyl, and halogens substituted benzenes. The lone pair of electrons at amide substituent serves as a p-electron contributor into the aromatic ring, hence increasing the stability and transition energy, which results in longer emission and low quantum yield for the aniline. The fluorescence of halogenated benzenes illustrates an increase in the HOMO-LUMO energy gap and a decrease in quantum yield associated with atomic size (F>Cl>Br>I). In this study the theoretical results are in line with experimental ones. The understanding of fluorescence and photophysical properties are of great importance in the identification of these compounds in the water.

关键词： Fluorescence     Photophysical properties     Effect of the substituent     Toxic aromatic compounds    

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A 14-year measurement of toxic elements in atmospheric particulates in Hong Kong from 1995 to 2008

Wei NIE,Tao WANG,Aijun DING,Xuehua ZHOU,Wenxing WANG

《环境科学与工程前沿（英文）》 2014年 第8卷 第4期   页码 553-560 doi: 10.1007/s11783-013-0523-2

摘要： Toxic elements in the atmosphere can enter and accumulate in the human body, seriously impacting human health. In this study, we analyzed a 14-year (1995–2008) measurement of three toxic elements (As, Cd and Cr) in PM in Hong Kong, China. The pollution of these toxic elements in Hong Kong was not serious. The trend analysis showed that As and Cr in PM increased at a statistically significant level ( <0.05) during the 14-year period, while the Cd in PM did not change significantly. Typical seasonal variations were observed for all three toxic elements, largely in relation to the Asian monsoon. Hourly 10-day backward trajectories were computed and categorised into four groups. The continental air masses showed much higher concentrations of the three toxic elements than the marine air masses. The abundances of As and Cd in the PM were much higher in the continental air masses than those in the marine air masses, while the abundances of Cr showed an opposite pattern. The trends of the three toxic elements in East China’s air mass were consistent with those in the overall data set of Hong Kong. Examination of the toxic element data recorded at urban sites and a roadside site also indicated a large contribution of external air masses to particulate As and Cd in Hong Kong. These results suggest that the long-range transport from the mainland of China is the dominant contributor to particulate As and Cd, while both local and long-distance sources determine the particulate Cr in Hong Kong.

关键词： toxic elements     increasing trends     seasonal variations     air masses     long-distance sources    

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The temporal changes of the concentration level of typical toxic organics in the river sediments around

Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong

《环境科学与工程前沿（英文）》 2018年 第12卷 第6期 doi: 10.1007/s11783-018-1054-7

摘要：

The current situation of typical organics in the sediments around Beijing was unclear.

56 kinds of typical toxic organics were detected in this article.

Historical data was compared with the data in this study.

The change of different organics in the sediments around Beijing was concluded.

关键词： Organic compounds     Endocrine disrupters     Sediments     Concentration     Temporal changes    

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Non-toxic, high selectivity process for the extraction of precious metals from waste printed circuit

《环境科学与工程前沿（英文）》 2023年 第17卷 第10期 doi: 10.1007/s11783-023-1723-z

摘要：

● Au, Ag and Pd were recovered from WPCBs with high efficiencies.

关键词： Thiosulfate     Printed circuit boards     Precious metals     Leaching     Hydrometallurgy    

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Photoelectrocatalytic generation of H and S from toxic HS by using a novel BiOI/WO nanoflake array photoanode

《能源前沿（英文）》 2021年 第15卷 第3期   页码 744-751 doi: 10.1007/s11708-021-0775-7

摘要： In this paper, a photoelectrocatalytic (PEC) recovery of toxic H2S into H2 and S system was proposed using a novel bismuth oxyiodide (BiOI)/ tungsten trioxide (WO3) nano-flake arrays (NFA) photoanode. The BiOI/WO3 NFA with a vertically aligned nanostructure were uniformly prepared on the conductive substrate via transformation of tungstate following an impregnating hydroxylation of BiI3. Compared to pure WO3 NFA, the BiOI/WO3 NFA promotes a significant increase of photocurrent by 200%. Owing to the excellent stability and photoactivity of the BiOI/WO3 NFA photoanode and I–/I 3− catalytic system, the PEC system toward splitting of H2S totally converted S2– into S without any polysulfide ( Sx n−) under solar-light irradiation. Moreover, H2 was simultaneously generated at a rate of about 0.867 mL/(h·cm). The proposed PEC H2S splitting system provides an efficient and sustainable route to recover H2 and S.

关键词： bismuth oxyiodide (BiOI)/ tungsten trioxide (WO3) nano-flake arrays (NFA)     photoelectrocatalytic (PEC)     H2S splitting     H2     S    

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有毒有害化学品环境污染及安全防治建议

魏复盛

《中国工程科学》 2001年 第3卷 第9期   页码 37-40

摘要：

文章简要介绍了国际上有毒有害化学品环境污染研究与安全防治的现状和趋势，同时对国内有关环境介质的污染状况作了分析。指出了这是一个国家的环境安全问题，阐述了它的重要性和紧迫性，建议组织力量进行调查研究，摸清国情，以便有针对性地制订法规标准，加强监管与防治。

关键词： 有毒化学品     环境污染     防治建议    

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Perspective on gallium-based room temperature liquid metal batteries

《能源前沿（英文）》 2022年 第16卷 第1期   页码 23-48 doi: 10.1007/s11708-022-0815-y

摘要： Recent years have witnessed a rapid development of deformable devices and epidermal electronics that are in urgent request for flexible batteries. The intrinsically soft and ductile conductive electrode materials can offer pivotal hints in extending the lifespan of devices under frequent deformation. Featuring inherent liquidity, metallicity, and biocompatibility, Ga-based room-temperature liquid metals (GBRTLMs) are potential candidates to fulfill the requirement of soft batteries. Herein, to illustrate the glamour of liquid components, high-temperature liquid metal batteries (HTLMBs) are briefly summarized from the aspects of principle, application, advantages, and drawbacks. Then, Ga-based liquid metals as main working electrodes in primary and secondary batteries are reviewed in terms of battery configurations, working mechanisms, and functions. Next, Ga-based liquid metals as auxiliary working electrodes in lithium and nonlithium batteries are also discussed, which work as functional self-healing additives to alleviate the degradation and enhance the durability and capacity of the battery system. After that, Ga-based liquid metals as interconnecting electrodes in multi-scenarios including photovoltaics solar cells, generators, and supercapacitors (SCs) are interpreted, respectively. The summary and perspective of Ga-based liquid metals as diverse battery materials are also focused on. Finally, it was suggested that tremendous endeavors are yet to be made in exploring the innovative battery chemistry, inherent reaction mechanism, and multifunctional integration of Ga-based liquid metal battery systems in the coming future.

关键词： liquid metals     soft electrodes     flexible batteries     deformable energy supply devices     epidermal electronics    

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标题 作者 时间 类型 操作

Cohort study of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis in China: evaluation

Yanhong Shou, Lu Yang, Yongsheng Yang, Xiaohua Zhu, Feng Li, Bo Yin, Yingyan Zheng, Jinhua Xu

期刊论文

Toxic effects of enrofloxacin on

Hongwei QIN, Liufang CHEN, Nan LU, Yahui ZHAO, Xing YUAN

期刊论文

Removal and recovery of toxic nanosized Cerium Oxide using eco-friendly Iron Oxide Nanoparticles

Kanha Gupta, Nitin Khandelwal, Gopala Krishna Darbha

期刊论文

Nanosized magnetite in low cost materials for remediation of water polluted with toxic metals, azo- and

María Fernanda HORST,Verónica LASSALLE,María Luján FERREIRA

期刊论文

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

期刊论文

fabricating photoluminescent carbon dots and its potential application as an efficient sensor probe for toxic

期刊论文

Impact and inhibitory mechanism of phenolic compounds on the formation of toxic Maillard reaction products

Jing TENG, Xiaoqian HU, Ningping TAO, Mingfu WANG

期刊论文

Concentrations of toxic heavy metals in ambient particulate matter in an industrial area of northeastern

PIAO Fengyuan, SUN Xiance, LIU Shuang, YAMAUCHI Toru

期刊论文

Insight into fluorescence properties of 14 selected toxic single-ring aromatic compounds in water: Experimental

Muhammad Farooq Saleem Khan, Jing Wu, Cheng Cheng, Mona Akbar, Chuanyang Liu, Bo Liu, Jian Shen, Yu Xin

期刊论文

A 14-year measurement of toxic elements in atmospheric particulates in Hong Kong from 1995 to 2008

Wei NIE,Tao WANG,Aijun DING,Xuehua ZHOU,Wenxing WANG

期刊论文

The temporal changes of the concentration level of typical toxic organics in the river sediments around

Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong

期刊论文

Non-toxic, high selectivity process for the extraction of precious metals from waste printed circuit

期刊论文

Photoelectrocatalytic generation of H and S from toxic HS by using a novel BiOI/WO nanoflake array photoanode

期刊论文

有毒有害化学品环境污染及安全防治建议

魏复盛

期刊论文

Perspective on gallium-based room temperature liquid metal batteries

期刊论文